Valneva's Lyme disease
vaccine candidate - VLA15

The Company is focusing its R&D expertise and resources to a large extend on the development of a much-needed vaccine against Lyme disease, the most common and one of the fastest growing vector-borne illnesses in the Northern Hemisphere for which there is no other clinical vaccine candidate in development worldwide.

Valneva recently reported positive Phase 1 interim data for its Lyme disease vaccine candidate VLA15 (Press release).

Valneva’s Phase 1 study VLA15-101 is an observer-blind, partially randomized, dose escalation trial that aims to evaluate the safety, tolerability and immunogenicity of its Lyme vaccine candidate VLA15. The study enrolled 179 healthy adults under 40 years of age in Europe and the US who were not previously infected with Borrelia burgdorferi.

The Company is committed to advance its Lyme vaccine candidate as quickly as possible into Phase II which is currently expected to commence in the second half of 2018, subject to regulatory clearances.

Valneva´s vaccine candidate VLA15, under Fast Track Designation by the FDA, is a multivalent, protein subunit vaccine that targets the outer surface protein A (OspA) of Borrelia and intended to protect against the majority of human pathogenic Borrelia species. VLA15 is designed to confer protection by raising antibodies that prevent Borrelia from migrating from ticks to humans after a bite.

Pre-clinical data showed that this vaccine candidate has the potential for protection against the majority of Borrelia species pathogenic for humans (Source).


The global market for a vaccine against Lyme disease is currently estimated at approximately €700 - €800 million annually1.

About Lyme disease

1 Company estimate supported by independent market studies

18th World Vaccine Congress 2018 - Presentation on Lyme disease
PR Valneva Reports Positive Phase I Interim Results for Its Lyme vaccine candidate VLA15
PR Valneva Receives FDA Fast Track Designation for its Lyme Disease Vaccine Candidate VLA15
17th World Vaccine Congress 2017 - Presentation on Lyme disease
Lyme Disease - A Tick-Transmitted Infection (brochure)
PR Valneva Receives FDA and European Approvals to Start Clinical Testing of Lyme Disease Vaccine Candidate

Media coverage
Panne d'innovation chez les grands industriels des vaccins, Les Echos, 16/04/2018
Prepare for a Bad Summer for Ticks, WSJ, 24/04/2017
Lyme disease is set to explode and we still don’t have a vaccine, New Scientist, 29/03/2017

This program is supported by the Vienna Business Agency.

Wirtschaftsagentur Wien
Please update your browser...